The biennium 2010-2011 has become a period of significant transformation of activities of the UNESCO Institute for Information Technologies in Education (IITE). These changes have been made possible thanks to the guidance of the UNESCO Director-General and Assistant Director-General for Education based on precise vision of IITE’s mission and its role within the Organization. The transitional processes were inspired by the IITE Medium-Term Strategy for 2008-2013 developed with the intellectual contribution of the IITE Governing Board.