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Background: In 2005, the resources needed to support orphans and vulnerable children in sub-Saharan Africa were estimated at US$1.1–4.1 billion. Approaches to support vulnerable children have changed considerably since then. This study updates previous estimates by including new types of support and information on support costs. Methods: We considered 16 types of support categorized as economic strengthening, education support, social care and community outreach, and program support. …