The Safe Schools Program (Safe Schools) was a five-year initiative (2003-2008) funded by the U.S. Agency for International Development (USAID), Office of Women in Development and implemented by DevTech Systems, Inc. (DevTech). This program was at the forefront of defining, understanding and addressing school-related gender-based violence (SRGBV). In 2003, gender-based violence in schools was considered a significant obstacle both to achieving the Education for All (EFA) goals, and to reducing the spread of HIV/AIDS. It was apparent, however, that additional research and new tools were required to better understand the issue and how to approach it. In response, the Office of Women in Development dedicated resources to the Safe Schools Program to address this issue through a series of ground-breaking interventions. This report details the design of the program, describes its interventions, and documents key impacts and lessons learned from implementation. The goal of Safe Schools was to reduce school-related gender-based violence in selected schools in Ghana and Malawi to support the longer-term goal of improving educational outcomes and reducing negative health outcomes for school children. Changes in student and teacher knowledge, attitudes and practices toward school-related gender-based violence were used to measure progress toward reducing gender violence.