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In 2007, an estimated total of 2 million children were living with HIV - eight times more than in 1990 - while both new infections and deaths among children have grown three-fold globally since 1990. Around 90% of these children live in sub-Saharan Africa, where 12.1 million children are estimated to have lost one or both parents to AIDS. This plenary presentation argues that children and families have been severely neglected in responses to HIV and AIDS. …