Aahung, a Karachi-based sexual and reproductive health non-profit organization, has developed a life skills-based education (LSBE) program for school-going adolescent girls and boys. This intervention provides young people with skills and knowledge related to adolescent reproductive health, such as accurate information about puberty and related changes, marital rights, peer pressure, sexual harassment and body protection, gender inequities, early marriage, nutrition, self-confidence, decision-making, and communication skills. Aahung’s case study of empowering girls through LSBE is a good practice with useful lessons for low and middle income countries with similar cultural contexts.