This document is the revised National HIV and AIDS, STI Policy for Ghana. It has been revised by the Ghana AIDS Commission in collaboration with the Ministry of Health, National AIDS and STI Control Programme (NACP) of the Ghana Health Service and key stakeholders, taking into account recent developments in the national and global response. The document provides useful information on the status of the epidemic, its consequences and interventions necessary to adequately respond to the epidemic and the policies and organisational structures that have been put in place to address the epidemic comprehensively.