The Islands of Southeast Asia Network on Male and Transgender Sexual Health (ISEAN) Community Leadership and Advocacy Framework is intended for use as a template for subregional and national advocacy to improve HIV prevention and care among MSM and transgender people. It sets out five Key Domains for Advocacy, provides suggestions for partnerships that would make advocacy more successful and outlines some indicative advocacy strategies. The Framework is supported by a Resource Guide (the Guide) that summarizes key global and regional commitments and guidelines and provides examples of work that has been done to remove access barriers for MSM and transgender people.