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This Insight is intended to advance the discussion on the impact of HIV and AIDS on children in three key ways: by drawing attention to the situation of children orphaned by AIDS and the limitations of current responses for the realization of their rights; by reviewing the options for the care of these children, highlighting effective experiences and lessons learned from family and local approaches; and by identifying ways in which local, national and international actors can effectively fulfil their responsibilities to safeguard the human rights of children, with particular focus on children …