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The National HIV Strategic Plan for the period 2016-2021 is a set of evidence-informed strategies focused on building one consolidated, unified, rights-based and decentralized HIV programme with services that are integrated in the general health services of the country. It builds on lessons learned from implementation of the National AIDS Strategy 2011-2016, its mid-term review and the Nepal HIV Investment Plan 2014-2016, and it applies recommendations from the AIDS Epidemic Model exercise and other strategic information from studies, surveys and assessments.