This document describes the Caribbean Regional Strategic Framework 2014-2018 with Section One as introduction. Section Two describes the PANCAP regional response to date, highlighting key achievements, challenges and gaps. Section Three presents an updated epidemiological profile and a discussion of the particular economic, social and cultural factors which impact on the regional response. Section Four describes the vision and goals of the CRSF, the strategic objectives and expected results. Section Five presents an overview of institutional arrangements, and Section Six describes how the impact of national and regional responses will be measured, monitored and evaluated.