This guide was developed as part of the international ‘Educate, empower and engage for healthy lives’ project. This guide was developed by a team of young people with personal experience as a young person who uses drugs and/or work with vulnerable young people. The guide was developed by the project team and then piloted in 4 countries (Kyrgyzstan, Mexico, Nigeria, and Portugal). The objective of the trainings, workshops and this guide is to promote healthy behaviours and lifestyle choices among young people who use drugs, or are at risk of using drugs, as well as contributing to the development of better youth policies that impact upon marginalised youth. Some of the activities have been drawn from a previous peer education guide produced by Youth RISE and other resources and activities that have proved effective in other peer education settings.