This monograph serves as a resource to enable a view on scaled up response through multi-sectoral support for risk reduction and impact mitigation of HIV in India. It draws on key achievements and lessons learnt from NACP I, II and III with regard to mainstreaming. The document focuses on the Department of AIDS Control’s (DAC) current response to the epidemic, which are priorities under NACP-IV and the rationale that guided the development of these priorities.