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In sub-Saharan Africa, an estimated 12 million children 17 years of age and younger have lost one or both parents to AIDS, and many more live with a chronically ill parent or guardian. Children affected by HIV and AIDS often face intensified poverty; inadequate food, shelter, and medical care; stigma and discrimination; mental distress; and other challenges. Despite recognition of the magnitude and negative consequences of these problems, there is a dearth of evidence as to what types of programs best improve the well-being of orphans and vulnerable children (OVC). …