The current National HIV Prevention Strategy (2015-2020) has adopted a results-based management approach with clear activities leading to outputs and outcomes. Eventually, these directly lead to the desired impacts as outlined in the revised 2015-2020 National Strategic Plan for HIV and AIDS (NSP). The primary objective of the current NSP is the achievement of the 90-90-90 targets by 2020. This National Prevention Strategy embraces a combination prevention approach for primary and secondary HIV prevention. The Strategy also presents cross-cutting contextual factors and determinants, which need to be addressed to create an enabling environment for sustained positive behaviours in Malawi. These include gender, human rights, culture, law/legislation, and capacity building. The strategy also presents monitoring and evaluation indicators for tracking the progress in its implementation. To enhance coordination in HIV prevention efforts, the Strategy presents key lead agencies for each strategic area.