This study seeks to look at the influence of program-level and contextual determinants that pose a challenge to the uptake of prevention of mother-to-child HIV transmission programs in sub-Saharan Africa. This study explore thes multilevel factors associated with "coverage in single dose nevirapine PMTCT programs." The study found that heterogeneity of nevirapine coverage between sites and programs was high- meaning that in these programs there was a high HIV prevalance, a higher proportion of persons with knowledge of PMTCT, and a lower percentage of rural population. The study found that there are several significant contextual determinants that prevent the uptake of prevention of PMTCT programs in sub-Saharan Africa, and that this warrants additional research to further define important multi-level and potentially modifiable determinants of performance of PMTCT programs.