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This handbook for students is the last in a series of three documents designed for educational planners, teachers and students on school health education and the prevention of HIV/AIDS and STDs. It includes some fifty-three student learning activities on prevention of HIV/AIDS and STDs. The activities are divided into four units: 1) basic knowledge on HIV/AIDS and STDs; 2) abstinence and postponement of first sexual contact; 3) practicing safer sex; and 4) counselling and support.