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In preparation for a school-based intervention in KwaZulu-Natal, South Africa, the authors conducted a cross-sectional survey of potential HIV risk factors in youth ages 14–17 (n=983). Boys were significantly more likely than girls to report lifetime sexual activity (37.7% v. 13.8%, P<0.01). Among boys and girls, 46.1% reported condom use at last sex. Discussion of condom use with a partner was the strongest predictor of condom use (boys, odds ratio (OR)=7.39; girls, OR=5.58, P<0.0001). …