The aim of the study was to explore young people's understanding and knowledge about why protective measures against HIV/AIDS, malaria and unplanned pregnancy are not taken by those at risk in Uganda. The study results were that the participants (all from secondary school in Kanungu Uganda) could identify reasons why preventive action was not taken. These reasons included misconceptions, the inpracticability of abstinence, and fear of side effects of several key interventions. The article argues that there is an apportunity to improve preventive measures by tackling these issues. This would involve more communication, reaching out to isolated communities, and the use of voluntary and government services to help youth.