The Fifth South African National HIV Prevalence, Incidence, Behaviour and Communication Survey, (SABSSM V), a population-based cross-sectional survey of households in South Africa, was designed to assess the prevalence and trends of key HIV–related indicators. The survey was conducted between January and December 2017 by the Human Sciences Research Council (HSRC) and provides information on national and sub-national progress toward HIV epidemic control in the country. This report summarizes the HIV epidemic and impact of South Africa’s national HIV response.