Adolescence is a time when gender disparities between boys and girls become more pronounced. While many boys stay focused on school, girls often have more responsibilities at home. These responsibilities limit girls’ opportunities for maintaining social networks, and social isolation can contribute to increasing the risk of dropping out of school, marrying early, and being in situations that leave them vulnerable to pregnancy and HIV infection. At their most recent annual meeting, the Interagency Youth Working Group focused on protecting and empowering adolescent girls. Sports programming was among the innovative approaches highlighted. This brief summarizes the discussion.