For the Swiss Agency for Development and Cooperation (SDC), contributing to the international AIDS response continues to be a priority and mainstreaming of HIV should be understood as a shared responsibility in all, or much, of cooperation work.SDC promotes strategies and approaches that are adapted to the local context and epidemiological scenario. It is essential to use a culturally, and gender sensitive and appropriate approach when responding to the epidemic. Mainstreaming of HIV can take place in cooperation activities in various epidemiological contexts with various aid modalities – through bilateral cooperation, humanitarian aid and multilateral aid.