The Conceptual Framework for Elimination of New HIV infections in Cambodia by 2020 is an important document that recommends key strategies and cost effective and high quality package of priority activities. With the aim of reaching Zero New HIV Infections, and in line with the 2012 WHO guidance the following interventions are being considered: accelerating HIV case detection among most-at-risk populations (MARPs), pregnant women, and partners of PLHIV on care and the immediate initiation of ART as Prevention.