This case study on the University of Zambia aimed at answering the following questions: In what ways has the University of Zambia been affected by HIV/AIDS? How has the university responded to these impacts? What steps is the university taking to control and limit the further spread of HIV/AIDS in its community? What HIV/AIDS-related teaching, research, publication, and advisory services has the university undertaken? How does the university propose to anticipate and address the larger impact of HIV/AIDS on the national labour market for university graduates? Should university access, including via distance education, be consciously increased to compensate for expected national losses in skilled professional personnel? Data collection was done through interviews and group discussions centred on the following topics: University policies and management; Personnel: University members living with HIV/AIDS; Core university operations; University functioning; Costs; Social life; University image and outreach.