The National Strategic Framework (NSF) for HIV and AIDS 2010/11 -2015/16 succeeds the MTP-III that came to an end in March 2010. The framework provides strategic policy, planning and implementation guidance and leadership for the national HIV and AIDS multi-sectoral response. The national response is premised on the understanding that HIV and AIDS remains the greatest socioeconomic development challenge in Namibia. The NSF marks a paradigm shift for the national response from doing “business as usual” to evidence and results based multi-sectoral and decentralised planning. NSF has mainstreamed gender and human rights in all aspects of the response planning and service delivery.