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South Africa's HIV prevalence among 15-24 year olds is one of the highest in the world. This systematic review looks at the evidence for youth HIV prevention in the country since 2000 and critically assesses interventions across four domains: study design and outcomes; intervention design; thematic focus and HIV causal pathways; and intervention delivery. Eight interventions were included in the review, all similar regarding content and objectives, but with variouis thematic foci, causal pathways, theoretical bases, delivery methods, intensity and duration. …