This manual is the outcome of a youth-led project by Restless Development Zambia (supported by Irish AID) to identify, document and highlight civil society anti-HIV and AIDS initiatives that have had proven awareness raising and programmatic impact in the education sector in Zambia. The manual has been devised and based upon the Southern African Development Community (SADC) HIV framework of seven best practice criteria, which include: Ethical Soundness; Effectiveness; Innovation; Relevance; Cost-effectiveness; Replicability and Sustainability. These criteria were used to assess and validate different elements of the various HIV and AIDS initiatives from diverse organisations categorized by the following themes: Peer Education; Sport; Capacity Building (Care and Support and OVC); Gender (Life Skills and Livelihoods) and Information Education Materials.