Curriculum development is one of the most noticeable areas requiring attention in higher education: a limited curriculum integration is cited as a general weakness of institutional responses to HIV and AIDS. In the immediate future, integration of HIV and AIDS into curriculum must be a priority for institutions and funders. This document can be used as a toolkit, a hand-book to successfully integrating HIV and AIDS into the curricula of higher education. It is based on case studies, offering a multidimensional benchmark of interventions that should serve as a model to other institutions.