The purpose of this report is to guide regional and global advocacy and inform political dialogue over the coming year, including in the contexts of the African Union Agenda 2063 and the post-2015 sustainable development agenda. The report outlines: „ the current progress, gaps and impact of HIV among young women and adolescent girls in Africa; „ how to adapt, given the dynamic context of the African continent, and what needs to be considered in the response; „ how to leverage the commitments of African leaders to end the AIDS epidemic and transform the lives of young women and adolescent girls on the continent.