This study fostered the prevention of, and strengthened response to, school-related gender-based violence (SRGBV) in South African schools, by adapting an effective, adult-centric, community-based GBV prevention— the Zero Tolerance Village Alliance—to help mitigate SRGBV among children in secondary school. This adapted, child-centric version—the ‘Zero Tolerance School Alliance” (ZTSA)—was implemented in 2016 and 2017 in one public secondary school in Vhembe district, Limpopo province, South Africa.