In 2011, the Division of Reproductive Health (DRH) in collaboration with FHI 360 undertook a review of adolescent and youth reproductive health programs in the country that included a desk review, mapping of youth serving organizations (YSOs), and interviews with stakeholders from the YSOs and development partners. The aim was to identify the key organizations involved in adolescent and youth sexual and reproductive health (AYSRH), compile a general inventory of their activities, and begin to assess the degree to which they are using evidenced-based interventions that are ready for national scale-up. This review was designed to enhance the DRH’s ability to coordinate AYSRH activities in the country. In 2012, this collection of Evidence-based AYSRH Interventions was further developed in an effort to prepare for the national devolution of health services to the county level. This report, as a result, provides a list of AYSRH evidenced-based interventions that county health managers and youth serving organizations (YSO) can chose from to guide adolescent and youth sexual and reproductive health interventions unique to specific areas in their counties.