What are Best Practices? What criteria can be used to define a Best Practice and how can Best Practices be used? How can we promote the use of Best Practices by program staff in the field? These are some of the questions that this manual seeks to answer in relation to HIV/AIDS interventions and programs with children and youth. In order to strengthen the member organisations' use of the Best Practice approach both as a tool and as a process, the two networks entered into a joint venture in 2003. One of the main components was the commissioning of a study to produce an overview of the relevance of Best Practices in international development work, as well as a discussion of how the concept of Best Practices can be meaningfully applied to practical program interventions of Danish NGOs and their South partners in their work on HIV/AIDS and children and youth. The expected outcome of the study was a Manual on Best Practices for HIVAIDS Programming with Children and Young People, which was again expected to contain the following: An introduction to the concept of Best Practices; a guideline for organisations wishing to implement Best Practice processes in their work with HIV/AIDS and children and youth; an analysis of limitations and opportunities in NGOs' work with Best Practices; and references to relevant literature and websites. The present document is that manual. While the primary target group for this publication is made up of Danish NGOs and their partners and counterparts in low income countries, it is envisaged that international NGOs and donors may also be inspired by the approach taken to Best Practice herein.